General
Preferred name
WAY 213613
Synonyms
CHEMBL1628669 ()
WAY-213613 hydrochloride (868359-05-1 free base) ()
WAY-213613 ()
WAY-213613 (hydrochloride) ()
WAY-213613 hydrochloride ()
P&D ID
PD021685
CAS
868359-05-1
2450268-84-3
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
High-quality chemical probes
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
WAY-213613 is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system[1][2]
PRICE
90
DESCRIPTION
WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC50 value of 85 nM. WAY-213613 can be used for the research of central nervous system[1].
DESCRIPTION
High affinity sigma1 ligand
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, non-substrate EAAT2 inhibitor
(Tocriscreen Plus)
DESCRIPTION
Potent, non-substrate EAAT2 inhibitor
(Tocriscreen Total)
DESCRIPTION
WAY 213613 is a potent and non-substrate inhibitor of EAAT2 (GLT-1), displaying > 44-fold selectivity over EAAT1 and EAAT3 (IC50 = 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1, respectively). WAY 213613 exhibits no activity towards ionotropic and metabotropic glutamate receptors.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WAY-213613 hydrochloride shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function and can be used for the research of central nervous system [1] [2].
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
20
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
High-quality chemical probes
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Tool Compound Set
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
414.0
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.26
TPSA
101.65
Fraction CSP3
0.12
Chiral centers
1.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Target
EAAT2
Excitatory amino acid transporter 2
Human EAAT1
Human EAAT2
Human EAAT3
SLC1A2
EAAT
Primary Target
Glutamate (EAAT) Transporters
MOA
Inhibitor
Excitatory amino acid transporter 2 inhibitor
glutamate inhibitor
Member status
member
Pathway
Membrane Transporter/Ion Channel
Metabolism
Source data
